![]() It should be noted that the use of OLE plays a significant role in health ( 14). Numerous studies have shown that OLE has numerous physiological properties, and the antioxidant, anti-inflammatory, antimicrobial, antiviral, hypolipidemic, and hypoglycemic effects of this compound have been proven in in-vitro and in-vivo studies ( 13- 15). Oleuropein is a heterocyclic ester of elenolic acid and 4,3-dihydroxyphenyl ethanol ( 13). Oleuropein (OLE) is one of the most abundant and significant phenolic compounds in olive fruit and leaves, and the bitterness of the olive fruit is due to the presence of this compounds. Phenolic compounds in olive fruit and leaves are among the most important factors with pharmacological properties. Polyphenols are a group of chemicals found in plants, fruits, and vegetables ( 12). ![]() Today, due to the different side effects of many artificial drugs, the use of plant and natural materials has been considered ( 12). This drug is the most common ointment for dressing second and third-degree burns and is used to prevent and treat burn wound infections ( 11). Silver sulfadiazine (SSD) belongs to a class of drugs known as sulfa antibiotics. Today, to treat a burn injury, the skin wound is usually washed, and all skin blisters are removed and cleaned, then the attached tissue is removed, necrotic tissue is shaved off, and standard topical antibiotics such as silver nitrate, mafenide acetate, and silver sulfadiazine are used to treat these wounds ( 10). Advances in wound healing and tissue repair methods have reduced the time of hospitalization and improved the quality of life of burns patients after treatment ( 9). Thus, various substances such as honey, fish oil, aloe vera, and potato have been used to treat burn wounds ( 8). Since ancient times, the preparation of ointment to reduce pain and accelerate the healing of burn wounds has been considered by physicians. There is no pain in third-degree burns due to the loss of sensory nerves, but the risk of infection and death in this type of burn injury is high ( 6, 7). In third-degree burns, the damage passes through the outer and middle layers of the skin, and the burn may also reach muscle and bone tissue. In second-degree burns, the outer and middle layers are damaged, which is accompanied by blisters. Blisters are not seen in this type of burn. In first-degree burns, only the outer layer of the skin is damaged, and the skin becomes only hot, red, and painful. ![]() To evaluate the severity of burns clinically, mild to severe injuries are classified in three degrees ( 5). According to the World Health Organization, about 11 million people suffer burns, which 300,000 of them die ( 3).īurns occur when skin cells or other tissues in the body are destroyed by hot liquids, hot objects, flames, chemicals, electricity, radioactivity, and friction with various objects ( 4). In terms of prevalence, after traffic accidents, falls, and personal violence, burns are the fourth most common type of injury worldwide ( 2). Burns remain a major public health issue all over the world, especially in the developing countries ( 1). ![]() Backgroundīurn is a type of injury to the skin or other tissues caused by heat or other reasons that can lead to disability or even death, and the resulting complications can reduce the quality of life. This study indicated that oleuropein has therapeutic value in treating burn wounds and thus supports its traditional use.īurn Wound Healing Oleuropein Rat 1. ![]()
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