![]() Most people (78%) who got Shingrix reported at least some pain at the injection site. Also, about 1 out of 10 reported grade 3 systemic reactions such as myalgia, fatigue, headache, shivering, fever, and gastrointestinal illness. About 1 out of 10 adults who received Shingrix reported grade 3 injection-site symptoms such as pain, redness, and swelling. In eight clinical trials of more than 10,000 immunocompetent participants 50 years or older, grade 3 reactions (vaccination-related reactions severe enough to prevent normal activities) were common after patients received Shingrix. Side Effects and Counseling for Reactogenicity In immunocompetent adults 70 years and older, vaccine efficacy remained high, at or above 84% in all 7 years after vaccination. 90.5% in a post hoc efficacy analysis of adult patients with immune-mediated diseases who were not taking immunosuppressive medication.87.2% in a post hoc efficacy analysis of adult patients with hematologic malignancies.68.2% among adult autologous hematopoietic cell transplant recipients.Vaccine efficacy was estimated among several immunocompromised groups: The efficacy of two doses of Shingrix for the prevention of postherpetic neuralgia (PHN) was high: 91.2% in adults aged 50 years and older, and 88.8% in adults aged 70 years and older. In a clinical trial of more than 30,000 participants, vaccine efficacy was 96.6% in adults aged 50 to 59 years, 97.4% in adults aged 60 to 69 years, and 91.3% in adults aged 70 years and older. Shingrix Vaccine Efficacy and Duration of ProtectionĪmong immunocompetent adults 50 years and older, the efficacy of two doses of Shingrix for the prevention of herpes zoster (shingles) was high among all age groups. ![]() The shingles vaccine does not contain thimerosal (a preservative containing mercury). ![]() ![]() A single dose after reconstitution is 0.5 mL. Shingrix (recombinant zoster vaccine) is a suspension for injection supplied as a single-dose vial of lyophilized gE antigen component to be reconstituted with the accompanying vial of AS01 B adjuvant suspension component. ![]()
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